Blocking immune signaling stalls inflammation and insulin resistance tied to obesity: Among the study's key findings was that inflammatory macrophage buildup is controlled by Netrin-1, which not only attracts more macrophages into fat tissue, but also prevents macrophages from carrying away pathogens and unwanted fat cells as the immune cells would normally do. Uncontrolled inflammation is known to damage arteries and vital organs.
"Our study results show that targeting Netrin-1 can lessen and possibly reverse the chronic inflammation and insulin resistance associated with major diseases tied to obesity, such as atherosclerosis and type II diabetes," says senior study investigator Kathryn Moore, PhD, a professor of medicine and cell biology at NYU Langone Medical Center. "Our goal, of course, is to let inflammation do the infection-fighting tasks it is supposed to do while stopping it from producing any disease-causing effects in fatty tissue that it is not supposed to do."
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