ScienceDirect.com - European Journal of Pharmacology - Curcumin restores diabetes induced neurochemical changes in the brainstem of Wistarrats

ScienceDirect.com - European Journal of Pharmacology - Curcumin restores diabetes induced neurochemical changes in the brainstem of Wistarrats: Curcumin and insulin treatment restored the alterations and maintained all parameters to near control. The results show that diabetes is associated with significant reduction in brainstem function coupled with altered cholinergic, insulin receptor and GLUT-3 gene expression. The present study indicates beneficial effect of curcumin in diabetic rats by regulating the cholinergic, insulin receptor and GLUT-3 in the brainstem similar to the responses obtained with insulin therapy.